Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_C17
(850 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 188 2e-47
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 184 2e-46
sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (C... 179 1e-44
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 173 5e-43
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 173 6e-43
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 171 2e-42
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 171 2e-42
sp|Q8HY81|CATS_CANFA Cathepsin S precursor 171 2e-42
sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor 171 2e-42
sp|Q8HY82|CATS_SAIBB Cathepsin S precursor 169 1e-41
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 188 bits (477), Expect = 2e-47
Identities = 99/270 (36%), Positives = 147/270 (54%), Gaps = 6/270 (2%)
Frame = +1
Query: 58 WEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEF 237
W +K ++NK+Y+ D RRNIWE+N+K I++HNL+ DLG +++GLN+F+DM +EF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 238 QSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITT------PNNIKLPDSWDWREKGAVSP 399
++ L+ +SR I + NN +PD DWRE G V+
Sbjct: 81 KAKYLT------------------EMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTE 122
Query: 400 VGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYA 579
V +Q N +AF+ G +EGQ +T S+QQ++DCS +GN+GC GG++ AY
Sbjct: 123 VKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQ 182
Query: 580 YLADYGSELDEDYPFVGCNSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAA 759
YL +G E + YP+ C+Y+K L K + V G E +L N V P + A
Sbjct: 183 YLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVA 242
Query: 760 IDASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
+D + F Y++GIY +CS VNHAV
Sbjct: 243 VDVE-SDFMMYRSGIYQSQTCSPLRVNHAV 271
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 184 bits (468), Expect = 2e-46
Identities = 99/272 (36%), Positives = 146/272 (53%), Gaps = 1/272 (0%)
Frame = +1
Query: 37 NSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFS 216
+ L+ W +K + Y + RR +WE+N+K I+ HN ++ GK F++ +N F
Sbjct: 22 DQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFG 81
Query: 217 DMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVS 396
DM +EF+ + + P + LP S DWR+KG V+
Sbjct: 82 DMTNEEFRQMM--------------GCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVT 127
Query: 397 PVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAY 576
PV NQ+ +AF+A GALEGQ F T L LS+Q ++DCS GN GC GG +++A+
Sbjct: 128 PVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAF 187
Query: 577 AYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPIS 753
Y+ + G + +E YP+V + CKY + F V+ GKE LM AV +GPIS
Sbjct: 188 QYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPIS 247
Query: 754 AAIDASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
A+DA +SF+ YK+GIY + CSS N++H V
Sbjct: 248 VAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGV 279
>sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (Catlrp-p)
Length = 333
Score = 179 bits (453), Expect = 1e-44
Identities = 108/275 (39%), Positives = 154/275 (56%), Gaps = 6/275 (2%)
Frame = +1
Query: 43 QLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDM 222
+L+ +W+D+KT + K YS E + +RR +WEEN++ IK HN + LGK F++ +N+F D
Sbjct: 24 KLDAEWKDWKTKYAKSYSPE-EALRRAVWEENMRMIKLHNKENSLGKNNFTMKMNKFGDQ 82
Query: 223 NQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPN-----NIKLPDSWDWREKG 387
+EF+ +I ++ +T P+ +I LPD DWRE+G
Sbjct: 83 TSEEFRKSIDNIPIPAA-------------------MTDPHAQNHVSIGLPDYKDWREEG 123
Query: 388 AVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILS 567
V+PV NQ +AFAAAGA+EGQ F T L LS Q ++DCS GN GC G
Sbjct: 124 YVTPVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTPLSVQNLLDCSKTVGNKGCQSGTAH 183
Query: 568 KAYAY-LADYGSELDEDYPFVGCNSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIG 744
+A+ Y L + G E + YP+ G + C+Y A+ ++ + E L AV +IG
Sbjct: 184 QAFEYVLKNKGLEAEATYPYEGKDGPCRYRSENASANITDYVNLP-PNELYLWVAVASIG 242
Query: 745 PISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
P+SAAIDAS SF+ Y GIY + +CSS VNHAV
Sbjct: 243 PVSAAIDASHDSFRFYNGGIYYEPNCSSYFVNHAV 277
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 173 bits (439), Expect = 5e-43
Identities = 98/273 (35%), Positives = 143/273 (52%), Gaps = 2/273 (0%)
Frame = +1
Query: 37 NSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFS 216
+ LN W +K + Y + RR +WE+N+K I+ HN ++ GK F++ +N F
Sbjct: 22 DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFG 81
Query: 217 DMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVS 396
DM +EF+ + + P ++P S DWREKG V+
Sbjct: 82 DMTNEEFRQVMNGFQNQKH--------------KKGKMFQEPLFAEIPKSVDWREKGYVT 127
Query: 397 PVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAY 576
PV NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC GG++ A+
Sbjct: 128 PVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAF 187
Query: 577 AYLADYGS-ELDEDYPFVGCNS-NCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPI 750
Y+ D G + +E YP++G ++ C Y + F + + +E LM AV +GPI
Sbjct: 188 RYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKALMKAVATLGPI 246
Query: 751 SAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
S AIDA SF+ YK+GIY D CSS +++H V
Sbjct: 247 SVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGV 279
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 173 bits (438), Expect = 6e-43
Identities = 101/281 (35%), Positives = 148/281 (52%), Gaps = 2/281 (0%)
Frame = +1
Query: 13 ASRIDSNVNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKF 192
A ++D N L+ DW +K + Y + RR +WE+N+K I+ HN ++ GK F
Sbjct: 18 APKLDQN----LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGF 73
Query: 193 SVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWD 372
S+ +N F DM +EF+ + + +++P S D
Sbjct: 74 SMAMNAFGDMTNEEFRQVMNGFQNQKH--------------KKGKVFHESLVLEVPKSVD 119
Query: 373 WREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSGCY 552
WREKG V+ V NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC
Sbjct: 120 WREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCN 179
Query: 553 GGILSKAYAYLADYGS-ELDEDYPFVGCNSN-CKYDKSLATVKPYEFKYVSRGKEADLMN 726
GG++ A+ Y+ D G + +E YP++G +N C Y + F + + +E LM
Sbjct: 180 GGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQ-REKALMK 238
Query: 727 AVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
AV +GPIS AIDA +SF+ YK+GIY D CSS +++H V
Sbjct: 239 AVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGV 279
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 171 bits (434), Expect = 2e-42
Identities = 97/269 (36%), Positives = 140/269 (52%), Gaps = 1/269 (0%)
Frame = +1
Query: 46 LNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMN 225
L W +K + N+ Y + RR +WE+N+K I+ HN ++ GK F++ +N F DM
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 226 QKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVG 405
+EF+ + + P + P S DWREKG V+PV
Sbjct: 85 SEEFRQVMNGFQNRKPR--------------KGKVFQEPLFYEAPRSVDWREKGYVTPVK 130
Query: 406 NQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAYL 585
NQ +AF+A GALEGQ F T L LS+Q ++DCS GN GC GG++ A+ Y+
Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYV 190
Query: 586 ADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAI 762
D G + +E YP+ +CKY+ + F + + ++A LM AV +GPIS AI
Sbjct: 191 QDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKA-LMKAVATVGPISVAI 249
Query: 763 DASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
DA SF YK GIY + CSS +++H V
Sbjct: 250 DAGHESFLFYKEGIYFEPDCSSEDMDHGV 278
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 171 bits (433), Expect = 2e-42
Identities = 94/266 (35%), Positives = 143/266 (53%), Gaps = 1/266 (0%)
Frame = +1
Query: 55 DWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKE 234
+W +K+ + Y + RR IWE+N++ I+ HN ++ G+ FS+ +N F DM +E
Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87
Query: 235 FQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQR 414
F+ + + P +K+P S DWREKG V+PV NQ
Sbjct: 88 FRQVVNGYRHQKH--------------KKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQG 133
Query: 415 NNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKAYAYLADY 594
+AF+A+G LEGQ F T L LS+Q ++DCS GN GC GG++ A+ Y+ +
Sbjct: 134 QCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKEN 193
Query: 595 GS-ELDEDYPFVGCNSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISAAIDAS 771
G + +E YP+ + +CKY A F + + ++A LM AV +GPIS A+DAS
Sbjct: 194 GGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKA-LMKAVATVGPISVAMDAS 252
Query: 772 PTSFKQYKTGIYDDTSCSSNNVNHAV 849
S + Y +GIY + +CSS N++H V
Sbjct: 253 HPSLQFYSSGIYYEPNCSSKNLDHGV 278
>sp|Q8HY81|CATS_CANFA Cathepsin S precursor
Length = 331
Score = 171 bits (433), Expect = 2e-42
Identities = 102/271 (37%), Positives = 145/271 (53%), Gaps = 3/271 (1%)
Frame = +1
Query: 46 LNKDWEDYKTIFNKKYSDETDLI-RRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDM 222
L+ W +K ++K+Y +E + + RR IWE+NLKF+ HNL+ +G + +G+N DM
Sbjct: 24 LDHHWNLWKKTYSKQYKEENEEVARRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDM 83
Query: 223 NQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPV 402
+E S + S+ RN + +N KLPDS DWREKG V+ V
Sbjct: 84 TGEEVISLMGSLRVPSQW-------------QRNVTYRSNSNQKLPDSVDWREKGCVTEV 130
Query: 403 GNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIY-YGNSGCYGGILSKAYA 579
Q + +AF+A GALE Q T L LS Q ++DCS YGN GC GG ++ A+
Sbjct: 131 KYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQ 190
Query: 580 YLADY-GSELDEDYPFVGCNSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPISA 756
Y+ D G + + YP+ N C+YD ++ + G E L AV N GP+S
Sbjct: 191 YIIDNNGIDSEASYPYKAMNGKCRYDSKKRAATCSKYTELPFGSEDALKEAVANKGPVSV 250
Query: 757 AIDASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
AIDAS SF Y++G+Y + SC + NVNH V
Sbjct: 251 AIDASHYSFFLYRSGVYYEPSC-TQNVNHGV 280
>sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor
Length = 334
Score = 171 bits (433), Expect = 2e-42
Identities = 99/273 (36%), Positives = 146/273 (53%), Gaps = 1/273 (0%)
Frame = +1
Query: 34 VNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEF 213
++S L+ +W+D+K +NK YS + + ++R +WEE LK IK HN + LGK F++ +NEF
Sbjct: 21 LDSSLDAEWQDWKIKYNKSYSLKEEKLKRVVWEEKLKMIKLHNRENSLGKNGFTMKMNEF 80
Query: 214 SDMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAV 393
D +EF+ ++ + + LP DWR+KG V
Sbjct: 81 GDQTDEEFRKMMIEISVWTHREGKSIMKREAGSI-------------LPKFVDWRKKGYV 127
Query: 394 SPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSGCYGGILSKA 573
+PV Q + +AFA GA+E Q T L LS Q ++DCS GN+GC GG A
Sbjct: 128 TPVRRQGDCDACWAFAVTGAIEAQAIWQTGKLTPLSVQNLVDCSKPQGNNGCLGGDTYNA 187
Query: 574 YAY-LADYGSELDEDYPFVGCNSNCKYDKSLATVKPYEFKYVSRGKEADLMNAVYNIGPI 750
+ Y L + G E + YP+ G + C+Y+ + + F + + ++ LM AV IGPI
Sbjct: 188 FQYVLHNGGLESEATYPYEGKDGPCRYNPKNSKAEITGFVSLPQSEDI-LMAAVATIGPI 246
Query: 751 SAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
+A IDAS SFK YK GIY + +CSS+ V H V
Sbjct: 247 TAGIDASHESFKNYKGGIYHEPNCSSDTVTHGV 279
>sp|Q8HY82|CATS_SAIBB Cathepsin S precursor
Length = 330
Score = 169 bits (427), Expect = 1e-41
Identities = 99/282 (35%), Positives = 147/282 (52%), Gaps = 8/282 (2%)
Frame = +1
Query: 28 SNVNSQLNKD------WEDYKTIFNKKYSDETD-LIRRNIWEENLKFIKQHNLQFDLGKT 186
S+ +QL+KD W +K + K+Y ++ + +RR IWE+NLKF+ HNL+ +G
Sbjct: 12 SSAVTQLHKDPTLDHHWNLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMH 71
Query: 187 KFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDS 366
+ +G+N DM +E S + S+ RN + N LPDS
Sbjct: 72 SYDLGMNHLGDMTSEEVMSLMSSLRVPNQW-------------QRNITYKSNPNQMLPDS 118
Query: 367 WDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSG 546
DWREKG V+ V Q + +AF+A GALE Q T L LS Q ++DCS YGN G
Sbjct: 119 VDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSEKYGNKG 178
Query: 547 CYGGILSKAYAYLAD-YGSELDEDYPFVGCNSNCKYDKSLATVKPYEFKYVSRGKEADLM 723
C GG +++A+ Y+ D G + + YP+ + C+YD ++ + G+E L
Sbjct: 179 CNGGFMTEAFQYIIDNKGIDSEASYPYKATDQKCQYDSKYRAATCSKYTELPYGREDVLK 238
Query: 724 NAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAV 849
AV N GP+ +DAS SF Y++G+Y D +C + VNH V
Sbjct: 239 EAVANKGPVCVGVDASHPSFFLYRSGVYYDPAC-TQKVNHGV 279
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.314 0.132 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,207,414
Number of Sequences: 369166
Number of extensions: 1399117
Number of successful extensions: 3607
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3187
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3310
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)