Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_G18
(518 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitoc... 153 3e-37
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 152 6e-37
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 152 6e-37
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 138 9e-33
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 135 8e-32
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 135 8e-32
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplas... 134 1e-31
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 133 3e-31
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytopl... 132 6e-31
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 124 2e-28
>sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 153 bits (386), Expect = 3e-37
Identities = 79/136 (58%), Positives = 90/136 (66%), Gaps = 1/136 (0%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
TIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+
Sbjct: 341 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQD---------- 390
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPN-HYLV 358
R+ ++E+ CV+TV+SG MTKDLA CIHGL NV+ N H+L
Sbjct: 391 -----------------LIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLN 433
Query: 359 TMDFLDAIAENFESKL 406
T DFLD I N + L
Sbjct: 434 TTDFLDTIKSNLDRAL 449
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 152 bits (383), Expect = 6e-37
Identities = 79/136 (58%), Positives = 89/136 (65%), Gaps = 1/136 (0%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
TIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+
Sbjct: 341 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQD---------- 390
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPN-HYLV 358
R+ +E+ CV+TV+SG MTKDLA CIHGL NV+ N H+L
Sbjct: 391 -----------------LIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLN 433
Query: 359 TMDFLDAIAENFESKL 406
T DFLD I N + L
Sbjct: 434 TSDFLDTIKSNLDRAL 449
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 421
Score = 152 bits (383), Expect = 6e-37
Identities = 79/136 (58%), Positives = 89/136 (65%), Gaps = 1/136 (0%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
TIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+
Sbjct: 310 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQD---------- 359
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPN-HYLV 358
R+ +E+ CV+TV+SG MTKDLA CIHGL NV+ N H+L
Sbjct: 360 -----------------LIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLN 402
Query: 359 TMDFLDAIAENFESKL 406
T DFLD I N + L
Sbjct: 403 TSDFLDTIKSNLDRAL 418
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 523
Score = 138 bits (347), Expect = 9e-33
Identities = 76/136 (55%), Positives = 84/136 (61%), Gaps = 1/136 (0%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
TIEAEAAHGTVTRHYREHQKG+PTST IASIFAWTRGLEHRGKLD NQ+
Sbjct: 413 TIEAEAAHGTVTRHYREHQKGRPTSTKGIASIFAWTRGLEHRGKLDGNQD---------- 462
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPN-HYLV 358
R+ E+ CV TV+ G MTKDLA CIHGL NV+ N H+L
Sbjct: 463 -----------------LIRFAQTREKVCVQTVE-GAMTKDLAGCIHGLSNVKLNEHFLN 504
Query: 359 TMDFLDAIAENFESKL 406
T DFLD I N + L
Sbjct: 505 TTDFLDTIKSNLDRAL 520
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 135 bits (339), Expect = 8e-32
Identities = 68/135 (50%), Positives = 85/135 (62%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
T+EAEAAHGTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR +LDNN E
Sbjct: 302 TVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSF------- 354
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVT 361
+ +E C++T+++G MTKDLAACI GL NVQ + YL T
Sbjct: 355 --------------------FAKALEEVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNT 394
Query: 362 MDFLDAIAENFESKL 406
+F+D + EN ++KL
Sbjct: 395 FEFMDKLGENLKAKL 409
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 135 bits (339), Expect = 8e-32
Identities = 68/135 (50%), Positives = 85/135 (62%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
T+EAEAAHGTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR +LDNN E
Sbjct: 302 TVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSF------- 354
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVT 361
+ +E C++T+++G MTKDLAACI GL NVQ + YL T
Sbjct: 355 --------------------FAKALEEVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNT 394
Query: 362 MDFLDAIAENFESKL 406
+F+D + EN ++KL
Sbjct: 395 FEFMDKLGENLKAKL 409
>sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 134 bits (338), Expect = 1e-31
Identities = 68/135 (50%), Positives = 86/135 (63%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
T+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLDNN E
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSF------- 354
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVT 361
+ + +E C++T+++G MTKDLAACI GL NVQ + YL T
Sbjct: 355 --------------------FANALEEVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNT 394
Query: 362 MDFLDAIAENFESKL 406
+F+D + EN ++KL
Sbjct: 395 FEFMDKLGENLKAKL 409
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 133 bits (334), Expect = 3e-31
Identities = 68/135 (50%), Positives = 85/135 (62%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
T+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLDNN E
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSF------- 354
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVT 361
+ +E C++T+++G MTKDLAACI GL NVQ + YL T
Sbjct: 355 --------------------FAKALEDVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNT 394
Query: 362 MDFLDAIAENFESKL 406
+F+D + EN ++KL
Sbjct: 395 FEFMDKLGENLKAKL 409
>sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 132 bits (331), Expect = 6e-31
Identities = 68/135 (50%), Positives = 85/135 (62%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
T+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAWTRGL HR KLDNN+E
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAF------- 354
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVT 361
+ + +E ++T+++G MTKDLAACI GL NVQ + YL T
Sbjct: 355 --------------------FANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNT 394
Query: 362 MDFLDAIAENFESKL 406
+F+D + EN + KL
Sbjct: 395 FEFMDKLGENLKIKL 409
>sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase)
(IDH) (NADP(+)-specific ICDH) (IDP)
Length = 415
Score = 124 bits (310), Expect = 2e-28
Identities = 69/135 (51%), Positives = 84/135 (62%)
Frame = +2
Query: 2 TIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQEXXXXXXXXTI 181
TIEAEAAHGTVTRHYR HQKG TSTN IASIFAWTRGL HR LDNN+
Sbjct: 304 TIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNER---------- 353
Query: 182 N*WCDNMLVDARLTCVQCFRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQPNHYLVT 361
L+D + +E AC+ V+SGKMTKDLA IHG K + +HYL T
Sbjct: 354 -------LLD----------FTEKLEAACIGAVESGKMTKDLALIIHGSK-LSRDHYLNT 395
Query: 362 MDFLDAIAENFESKL 406
+F+DA+A+ +++L
Sbjct: 396 EEFIDAVADELKARL 410
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,551,597
Number of Sequences: 369166
Number of extensions: 1082642
Number of successful extensions: 2551
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2439
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2535
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3403581975
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)