Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_B22
(797 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13233|M3K1_HUMAN Mitogen-activated protein kinase kinas... 121 2e-27
sp|P53349|M3K1_MOUSE Mitogen-activated protein kinase kinas... 121 3e-27
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 120 4e-27
sp|Q12236|KOK0_YEAST Probable serine/threonine-protein kina... 119 1e-26
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 119 1e-26
sp|Q62925|M3K1_RAT Mitogen-activated protein kinase kinase ... 119 1e-26
sp|Q9Y7J6|KOIA_SCHPO Putative serine/threonine-protein kina... 116 6e-26
sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinas... 115 2e-25
sp|P27636|CDC15_YEAST Cell division control protein 15 114 3e-25
sp|P50527|SHK1_SCHPO Serine/threonine-protein kinase pak1/shk1 113 5e-25
>sp|Q13233|M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase
kinase 1) (MEK kinase 1) (MEKK 1)
Length = 1495
Score = 121 bits (304), Expect = 2e-27
Identities = 81/251 (32%), Positives = 133/251 (52%), Gaps = 10/251 (3%)
Frame = +3
Query: 63 VAVGQFSQVYTARIVGNETVILMKRYTVV------EQSYKPVLRELVSFAKLDDHPRIIN 224
+ +G FS Y A+ VG T++ +K+ T V ++ LRE + +HP II
Sbjct: 1232 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1291
Query: 225 LLGFFKDELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSFLHKNRIIHC 404
+LG ++ + + +E M GS+ + + E ++ ++ Q+L+GLS+LH+N+IIH
Sbjct: 1292 MLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHR 1351
Query: 405 DLKSSNILLDN-NLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKI 581
D+K +N+L+D+ ++I+ F + LA + T E F GT FMAPEVL Q+
Sbjct: 1352 DVKGANLLIDSTGQRLRIADFGAAARLA-SKGTGAGE-FQGQLLGTIAFMAPEVLRGQQY 1409
Query: 582 TRKSDVWSFGAVLVELVTGRQPFYGLESIN---IILKIADEQTIDYVpreGMSDHLRDFI 752
R DVWS G ++E+ + P+ + N +I KIA T +P +S LRD
Sbjct: 1410 GRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSH-LSPGLRDVA 1468
Query: 753 AKCLTGKRKDR 785
+CL + +DR
Sbjct: 1469 LRCLELQPQDR 1479
>sp|P53349|M3K1_MOUSE Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase
kinase 1) (MEK kinase 1) (MEKK 1)
Length = 1493
Score = 121 bits (303), Expect = 3e-27
Identities = 81/251 (32%), Positives = 133/251 (52%), Gaps = 10/251 (3%)
Frame = +3
Query: 63 VAVGQFSQVYTARIVGNETVILMKRYTVV------EQSYKPVLRELVSFAKLDDHPRIIN 224
+ +G FS Y A+ VG T++ +K+ T V ++ LRE + +HP II
Sbjct: 1230 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHPNIIR 1289
Query: 225 LLGFFKDELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSFLHKNRIIHC 404
+LG ++ + + +E M GS+ + + E ++ ++ Q+L+GLS+LH+N+IIH
Sbjct: 1290 MLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHR 1349
Query: 405 DLKSSNILLDN-NLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKI 581
D+K +N+L+D+ ++I+ F + LA + T E F GT FMAPEVL Q+
Sbjct: 1350 DVKGANLLIDSTGQRLRIADFGAAARLA-SKGTGAGE-FQGQLLGTIAFMAPEVLRGQQY 1407
Query: 582 TRKSDVWSFGAVLVELVTGRQPFYGLESIN---IILKIADEQTIDYVpreGMSDHLRDFI 752
R DVWS G ++E+ + P+ + N +I KIA T +P +S LRD
Sbjct: 1408 GRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSH-LSPGLRDVA 1466
Query: 753 AKCLTGKRKDR 785
+CL + +DR
Sbjct: 1467 VRCLELQPQDR 1477
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 120 bits (301), Expect = 4e-27
Identities = 71/193 (36%), Positives = 112/193 (58%), Gaps = 2/193 (1%)
Frame = +3
Query: 207 HPRIINLLGFFKD--ELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSFL 380
H RI+ G +D E I ME+M GS+ +K ++ E + RK++ QIL+G+S+L
Sbjct: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
Query: 381 HKNRIIHCDLKSSNILLDNNLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPE 560
H N I+H D+K +NIL D+ ++K+ F SK L + MS M+S GT +M+PE
Sbjct: 481 HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL---QTICMSGTGMRSVTGTPYWMSPE 537
Query: 561 VLIDQKITRKSDVWSFGAVLVELVTGRQPFYGLESINIILKIADEQTIDYVpreGMSDHL 740
V+ + RK+DVWS G +VE++T + P+ E++ I KIA + T +P +S+H
Sbjct: 538 VISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSH-ISEHG 596
Query: 741 RDFIAKCLTGKRK 779
RDF+ + R+
Sbjct: 597 RDFLRRIFVEARQ 609
>sp|Q12236|KOK0_YEAST Probable serine/threonine-protein kinase YOL100W
Length = 1081
Score = 119 bits (298), Expect = 1e-26
Identities = 68/226 (30%), Positives = 114/226 (50%), Gaps = 5/226 (2%)
Frame = +3
Query: 123 ILMKRYTVVEQSYKPVLRELVSFAKLDDHPRIINLLGFFKDELYFYIAMEHMERGSLHFY 302
+L K Y + ++ K V E + KL++ P ++ L F+DE Y +E+ G
Sbjct: 209 VLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSL 268
Query: 303 IKNNSSINEDLIRKWSLQILQGLSFLHKNRIIHCDLKSSNILLDNNLDIKISGFSLSKYL 482
+K S++E R ++ QI+ + +LH N IIH D+K NILLD + IK++ F +K L
Sbjct: 269 MKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLL 328
Query: 483 AGANSTVMSEGF-----MQSKPGTCNFMAPEVLIDQKITRKSDVWSFGAVLVELVTGRQP 647
N++V + +S GT +++PE+L D + D+W+FG +L +++ G+ P
Sbjct: 329 NPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPP 388
Query: 648 FYGLESINIILKIADEQTIDYVpreGMSDHLRDFIAKCLTGKRKDR 785
F ++ N L + Y G +RD + K L K DR
Sbjct: 389 F---KATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILV-KNLDR 430
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 119 bits (298), Expect = 1e-26
Identities = 70/193 (36%), Positives = 112/193 (58%), Gaps = 2/193 (1%)
Frame = +3
Query: 207 HPRIINLLGFFKD--ELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSFL 380
H RI+ G +D E I ME+M GS+ +K ++ E + RK++ QIL+G+S+L
Sbjct: 421 HERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
Query: 381 HKNRIIHCDLKSSNILLDNNLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPE 560
H N I+H D+K +NIL D+ ++K+ F SK L + MS ++S GT +M+PE
Sbjct: 481 HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL---QTICMSGTGIRSVTGTPYWMSPE 537
Query: 561 VLIDQKITRKSDVWSFGAVLVELVTGRQPFYGLESINIILKIADEQTIDYVpreGMSDHL 740
V+ + RK+DVWS G +VE++T + P+ E++ I KIA + T +P +S+H
Sbjct: 538 VISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSH-ISEHG 596
Query: 741 RDFIAKCLTGKRK 779
RDF+ + R+
Sbjct: 597 RDFLRRIFVEARQ 609
>sp|Q62925|M3K1_RAT Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase
kinase 1) (MEK kinase 1) (MEKK 1)
Length = 1493
Score = 119 bits (298), Expect = 1e-26
Identities = 80/251 (31%), Positives = 132/251 (52%), Gaps = 10/251 (3%)
Frame = +3
Query: 63 VAVGQFSQVYTARIVGNETVILMKRYTVV------EQSYKPVLRELVSFAKLDDHPRIIN 224
+ +G FS Y A+ VG T++ +K+ T V ++ LRE + +HP II
Sbjct: 1230 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1289
Query: 225 LLGFFKDELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGLSFLHKNRIIHC 404
+LG ++ + + +E M S+ + + E ++ ++ Q+L+GLS+LH+N+IIH
Sbjct: 1290 MLGATCEKSNYNLFIEWMAGASVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHR 1349
Query: 405 DLKSSNILLDN-NLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKI 581
D+K +N+L+D+ ++I+ F + LA + T E F GT FMAPEVL Q+
Sbjct: 1350 DVKGANLLIDSTGQRLRIADFGAAARLA-SKGTGAGE-FQGQLLGTIAFMAPEVLRGQQY 1407
Query: 582 TRKSDVWSFGAVLVELVTGRQPFYGLESIN---IILKIADEQTIDYVpreGMSDHLRDFI 752
R DVWS G ++E+ + P+ + N +I KIA T +P +S LRD
Sbjct: 1408 GRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSH-LSPGLRDVA 1466
Query: 753 AKCLTGKRKDR 785
+CL + +DR
Sbjct: 1467 LRCLELQPQDR 1477
>sp|Q9Y7J6|KOIA_SCHPO Putative serine/threonine-protein kinase C1778.10c
Length = 550
Score = 116 bits (291), Expect = 6e-26
Identities = 66/193 (34%), Positives = 103/193 (53%), Gaps = 5/193 (2%)
Frame = +3
Query: 123 ILMKRYTVVEQSYKPVLRELVSFAKLDDHPRIINLLGFFKDELYFYIAMEHMERGSLHFY 302
+L K+Y V E K V E S +L+ P I L F+D+L Y +E G L Y
Sbjct: 84 VLDKKYIVKENKVKYVNIERDSMMRLNGFPGISRLFHTFQDDLKLYYVLELAPNGELLQY 143
Query: 303 IKNNSSINEDLIRKWSLQILQGLSFLHKNRIIHCDLKSSNILLDNNLDIKISGFSLS--- 473
IK ++E+ +R ++ +IL + ++H IIH DLK NIL D N+ +KI+ F +
Sbjct: 144 IKKYRFLDENCVRFYAAEILSSIEYMHSCGIIHRDLKPENILFDGNMHVKITDFGTAKIL 203
Query: 474 --KYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKITRKSDVWSFGAVLVELVTGRQP 647
KY+ + T F+ GT ++APE+L Q +++ SD+W+F V+ +++ G P
Sbjct: 204 PPKYVNSPDYTTFPSSFV----GTAEYVAPELLSRQVVSKSSDLWAFACVVYQMIVGSPP 259
Query: 648 FYGLESINIILKI 686
F+G NI KI
Sbjct: 260 FHGSNPNNIFKKI 272
>sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase
kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis
signal-regulating kinase 1) (ASK-1)
Length = 1374
Score = 115 bits (287), Expect = 2e-25
Identities = 79/250 (31%), Positives = 125/250 (50%), Gaps = 9/250 (3%)
Frame = +3
Query: 39 ELIEGNNHVAVGQ--FSQVYTARIVGNETVILMKRYTVVEQSYKPVLRELVSFAKLDDHP 212
E E + V +G+ + VY R + N+ I +K + Y L E ++ K H
Sbjct: 676 EYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHK 735
Query: 213 RIINLLGFFKDELYFYIAMEHMERGSLHFYIKNN---SSINEDLIRKWSLQILQGLSFLH 383
I+ LG F + + I ME + GSL +++ NE I ++ QIL+GL +LH
Sbjct: 736 NIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLH 795
Query: 384 KNRIIHCDLKSSNILLDNNLDI-KISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPE 560
N+I+H D+K N+L++ + KIS F SK LAG N ++ GT +MAPE
Sbjct: 796 DNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCT------ETFTGTLQYMAPE 849
Query: 561 VLI--DQKITRKSDVWSFGAVLVELVTGRQPFYGL-ESINIILKIADEQTIDYVpreGMS 731
++ + + +D+WS G ++E+ TG+ PFY L E + K+ + +P E MS
Sbjct: 850 IIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIP-ESMS 908
Query: 732 DHLRDFIAKC 761
+ FI KC
Sbjct: 909 AEAKAFILKC 918
>sp|P27636|CDC15_YEAST Cell division control protein 15
Length = 974
Score = 114 bits (285), Expect = 3e-25
Identities = 71/243 (29%), Positives = 120/243 (49%), Gaps = 1/243 (0%)
Frame = +3
Query: 72 GQFSQVYTARIVGNETVILMKRYTVVEQSYKPVLRELVSFAKLDDHPRIINLLGFFKDEL 251
G + VY A + V+ +K + +S K +H I+ GF +
Sbjct: 34 GSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSY 93
Query: 252 YFYIAMEHMERGSLHFYIKNNSS-INEDLIRKWSLQILQGLSFLHKNRIIHCDLKSSNIL 428
YI +E+ GSL I +S+ ++E+ + + Q L GL +LH +IH D+K++NIL
Sbjct: 94 ELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANIL 153
Query: 429 LDNNLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFMAPEVLIDQKITRKSDVWSF 608
L + +K++ F +S + + T+ GT N+MAPE+L ++ + SD+WS
Sbjct: 154 LSADNTVKLADFGVSTIVNSSALTLA---------GTLNWMAPEILGNRGASTLSDIWSL 204
Query: 609 GAVLVELVTGRQPFYGLESINIILKIADEQTIDYVpreGMSDHLRDFIAKCLTGKRKDRW 788
GA +VE++T P++ L NI + ++ Y P S+ L+DF++KC R
Sbjct: 205 GATVVEMLTKNPPYHNLTDANIYYAVEND---TYYPPSSFSEPLKDFLSKCFVKNMYKRP 261
Query: 789 NAD 797
AD
Sbjct: 262 TAD 264
>sp|P50527|SHK1_SCHPO Serine/threonine-protein kinase pak1/shk1
Length = 658
Score = 113 bits (283), Expect = 5e-25
Identities = 83/258 (32%), Positives = 125/258 (48%), Gaps = 2/258 (0%)
Frame = +3
Query: 18 CEIKNFGELIEGNNHVAVGQFSQVYTARIVGNETVILMKRYTVVEQSYKPVLRELVSFAK 197
C KN L + G VY+AR VG + +K+ + +Q K + + K
Sbjct: 377 CNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVMK 436
Query: 198 LDDHPRIINLLG--FFKDELYFYIAMEHMERGSLHFYIKNNSSINEDLIRKWSLQILQGL 371
H I+N + F+K EL+ + ME+M GSL + NN+ ++E I + L+GL
Sbjct: 437 SHHHKNIVNFIDTFFYKSELW--MVMEYMRGGSLTEVVTNNT-LSEGQIAAICKETLEGL 493
Query: 372 SFLHKNRIIHCDLKSSNILLDNNLDIKISGFSLSKYLAGANSTVMSEGFMQSKPGTCNFM 551
LH+N I+H D+KS NILL DIK++ F + A +S + M GT +M
Sbjct: 494 QHLHENGIVHRDIKSDNILLSLQGDIKLTDFG---FCAQIDSNMTKRTTMV---GTPYWM 547
Query: 552 APEVLIDQKITRKSDVWSFGAVLVELVTGRQPFYGLESINIILKIADEQTIDYVpreGMS 731
APEV+ ++ K DVWS G + +E+V G P+ + + IA T E +S
Sbjct: 548 APEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLS 607
Query: 732 DHLRDFIAKCLTGKRKDR 785
DF++K LT K R
Sbjct: 608 SVFHDFLSKSLTVNPKQR 625
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,717,362
Number of Sequences: 369166
Number of extensions: 2012999
Number of successful extensions: 8683
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6610
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6945
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7522142940
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)